Header Ads

Transport Secretary Grant Shapps warns Covid vaccines might not work on South African strain.... just hours after Pfizer study finds key mutation in super-infectious variant has NO effect on their jab

 UK Transport Secretary Grant Shapps warned today the current wave of vaccines might not protect against the South African strain of coronavirus.

Mr Shapps said introducing a mandatory test and release system for travellers coming into the UK had become 'much more urgent' because of the threat the variant poses to Britain's mass vaccination programme.

But there was confusion about the timing of his comments, which came just hours after a study by Pfizer/BioNTech suggested their vaccine could be just as effective against a mutation in the super-transmissible strain.

Amid international fears about the South African strain, thought to be at least 60 per cent more infectious than regular Covid, the UK has made it compulsory for travellers to test negative when they arrive in the country. 

Mr Shapps told Sky News: 'This is an extra check and we're doing this now because there are these variants that we're very keen to keep out of the country, like the South African variant, for example. 

'There are the concerns about the South African one in particular about how effective the vaccine would be against it so we simply cannot take chances. So today because of that variant it has become much more urgent.' 

The Pfizer study – which hasn't been peer-reviewed yet – tested how well the vaccine worked on the key N501Y mutation, an alteration on the virus's spike protein which is thought to be responsible for making it far more infectious than regular Covid. 

And because current vaccines work by training the immune system to recognise the virus's spike protein and attack it, there were fears this change could render jabs useless, or less effective. 

Results showed that neutralising antibodies were made against the mutation, which is also found in the highly-infectious Kent variant that is spreading rapidly across the UK. But both strains contain a catalogue of mutations, and the researchers have yet to prove that the vaccine works against them all. 


UK Transport Secretary Grant Shapps warned today the current wave of vaccines might not protect against the South African strain of coronavirus

UK Transport Secretary Grant Shapps warned today the current wave of vaccines might not protect against the South African strain of coronavirus

The mutations of the coronavirus has caused changes to the spike protein on its outside (shown in red), which is what the virus uses to attach to the human body (Original illustration of the virus by the US Centers for Disease Control and Prevention)

The mutations of the coronavirus has caused changes to the spike protein on its outside (shown in red), which is what the virus uses to attach to the human body (Original illustration of the virus by the US Centers for Disease Control and Prevention)

Dr. Michael Forino, right, gets the Pfizer-BioNTech COVID-19 vaccine at St. Joseph Hospital in Orange, California on Thursday

Dr. Michael Forino, right, gets the Pfizer-BioNTech COVID-19 vaccine at St. Joseph Hospital in Orange, California on Thursday


The researchers took blood samples from vaccinated patients and exposed them to a strain of the virus with the N501Y mutation.


Phil Dormitzer, one of Pfizer's top viral vaccine scientists, said the vaccine stimulated a strong immune response against the altered virus, which he described as 'good news'. 

However, the findings are limited because the research only studied the N501Y mutation and did not look at the full set of alterations found in either the new UK mutant strain or the South African one. 

Both strains have more than a dozen mutations, although most of them have no impact on the way it spreads and affects people.

Another mutation found in the South African variant, called E484K, which is not found in the UK version, is also concerning. It also seems to help the virus disguise part of its signature spike protein.

Dr Dormitzer said it was encouraging that the vaccine appears effective against the N501Y mutation, as well as 15 other mutations the company has previously tested against.

'So we've now tested 16 different mutations, and none of them have really had any significant impact. That's the good news,' he said. 'That doesn't mean that the 17th won't.'

The researchers plan to run similar tests to see if the vaccine is effective against other mutations found in the UK and South African variants and hope to have more data within weeks. 

One top scientist investigating the variants in the UK called the findings 'misleading'. Professor Ravi Gupta, a microbiologist at the University of Cambridge, said: 'This work should be ignored until properly conducted work is made available.' 

Other experts welcomed the findings and said they were 'useful', despite not being proof that the vaccine works against the two exact mutant strains.

Sian Griffiths, who co-chaired the Hong Kong inquiry into the 2003 SARS outbreak, said a US university report into the Pfizer vaccine's impact on UK and South Africa coronavirus variants is 'good news'.

Professor Griffiths, an epidemiologist who also serves on an advisory board for Public Health England, told BBC Breakfast: 'There's some good news this morning – it's not a peer-reviewed paper yet but it's a report from Texas University where they took blood from patients who had been immunised and tested it against both the Kent and the South African strain and the results were very positive, meaning that the Pfizer/BioNTech vaccine does protect against those variants and also other variants.'

She said the UK's 'good genomics' had allowed scientists here to understand the new variant which pushed infections up in London and the South East of England.

She said: 'Other countries are needing to do more work on which variant it is that's pushing their numbers up, and what we need to do is have these amazing scientific advances that we've made through the pandemic apply to making sure that vaccines do cover variants and therefore provide protection.

'So the good news this morning is that it appears that the Pfizer/BioNTech vaccine does protect against the South Africa strain, so people can rest assured that that particular strain isn't escaping the population.'

Scientists have expressed concern that vaccines being rolled out may not be able to protect against the new variants, particularly the one that emerged in South Africa.

Simon Clarke, an associate professor in cellular microbiology at the University of Reading, said this week that while both variants had some features in common, the one found in South Africa 'has a number additional mutations' that included more extensive alterations to the spike protein. 

The British strain, which first emerged in Kent in September, has been shown to be about 50 per cent more infectious than regular Covid. 

Scientists say the South African strain is even more infectious than the Kent one, although studies are still ongoing to put an exact figure on its transmissibility.  

But experts have told MailOnline there was no publicly-available data to suggest any of the new strains possesses the ability to escape the current iteration of jabs, even though they are more transmissible.

Professor Ian Jones, a virologist at the University of Reading, claimed he was 'almost certain' the vaccines will still be effective at some level.

He added that, in the unlikely event any new strain does makes vaccines redundant, it would take 'a few days or less' to tweak the jabs to target them.    

Professor Jones told MailOnline: 'At the moment there is no data on the ability of either the UK or SA variants to evade the immune response generated by the vaccine.

'The vaccines all produced multiple antibodies that block the virus-receptor interaction and while the changes in the variants might dodge a few of these they are unlikely to dodge all of them so it is almost certain the vaccine will still be effective at some level. 

'And as long as severe Covid is prevented even a partially effective vaccine would be useful. If a change in the vaccine was required the genetic alternation required could be done in a few days but of course the scale up to millions of doses will take time.'

Vaccine makers have said they are already looking at ways to tweak their jabs to protect people from new variants. 

Professor Sarah Gilbert, one of the leading scientists behind the Oxford/AstraZeneca vaccine, told the BBC today: 'We are looking at how well [the vaccines] work on these new variants and others that will come in the future. 

'And we're also thinking about what we'll need to do if it ever becomes necessary to replace the version of the vaccine we're using now with a new one. 

'We don't think we're at that point yet, there's no reason to suppose we need to make a switch now but it is possible that in the future we need to make a tweak, a change, to the vaccine. 

'So, with my team, I'm still working on how we make that change really quickly if we ever need to.'

Asked how quickly that change could come if needed, Professor Gilbert added: 'We don't expect to have to make a switch in the near future. But we're thinking that this vaccine is going to be used over a period of many years probably.

'As with flu vaccines we have a new version every year, which takes into account the changes in flu viruses circulating. Something similar is probably going to have to happen with the coronavirus vaccines.

'I don't think it's necessarily going to be a very rapid switch that we have to make. But what we might be looking at is when we're coming round to planning vaccinations for next autumn, thinking about another wave at end of 2021, which is a theoretical possibility, we will be considering whether to continue with the same version [of the vaccine] or a different version.'   

German firm BioNTech, which helped deliver the Pfizer vaccine approved in the UK last month, said it could use existing technology to produce a new vaccine against mutations of coronavirus in six weeks.

The team's vaccine uses brand-new mRNA technology, which BioNTech's chief executive says can be engineered much more easily than traditional vaccines. 

3 comments: